Chromosome studies in 12 solid tumours from children
نویسندگان
چکیده
منابع مشابه
Chromosome studies of solid tumours.
Introduction Cytogenetic analysis of malignant cells very often indicates acquired chromosome changes-that is, deviations from the normal constitutional 46,XX or 46,XY karyotype. Much of what we know about these changes is derived from studying leukaemias and lymphomas. Many of these abnormalities are nonrandom, and particular chromosome changes are consistently found in particular disease type...
متن کاملCytogenetic investigations of solid tumours of children.
The association of non-random chromosome abnormalities with solid tumours of childhood may improve accuracy of diagnosis and prognosis and lead to a better understanding of their biology. In a pilot study in the Northern region of England fresh tumour biopsy specimens were obtained from 39 to 72 consecutive solid tumours in children who presented over a period of 21 months. Cytogenetic analysis...
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Interleukin (IL)-12 is the key cytokine in the initiation of a Th1 response and has shown promise as an anti-cancer agent; however, clinical trials involving IL-12 have been unsuccessful due to toxic side-effects. To address this issue, lentiviral vectors were used to transduce tumour cell lines that were injected as an autologous tumour cell vaccine. The focus of the current study was to test ...
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CONTEXT The only genetic locus universally accepted to be important as a risk factor for late-onset Alzheimer disease (AD) is the apolipoprotein E (APOE) locus on chromosome 19. However, this locus does not account for all the risk in late-onset disease, and a recent report has suggested a second locus on chromosome 12p11-12. OBJECTIVE To look for evidence of linkage on chromosome 12 and to t...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1968
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1968.48